It is possible to lose weight by drinking smoothies, but it depends on the ingredients and how the smoothie fits into your overall diet and lifestyle. Smoothies that are made with nutrient-dense, whole foods and contain a balance of protein, healthy fats, and carbohydrates can be a part of a healthy weight loss plan. However, if the smoothies are loaded with sugar and calories, they can contribute to weight gain. Additionally, relying solely on smoothies for weight loss is not recommended as it is important to have a balanced and varied diet. Exercise and other healthy lifestyle habits also play a crucial role in weight loss.